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| Nomenclature |
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Symbol:
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Tg(H2-Ea-G6pc2)69Tkay
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Name:
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transgene insertion 69, Thomas Kay
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MGI ID: |
MGI:3790748 |
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Transgene:
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Tg(H2-Ea-G6pc2)69Tkay
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a protein-coding region of glucose-6-phosphatase, catalytic, 2, G6pc2, cloned from the murine NIT-1insulinoma cell line under the control of a 1.8-kb fragment encoding nucleotides -1,903 through -39 of the 5' flanking sequence of the MHC Class II gene, H2-Ea (k allele). Expression of G6pc2 was verified using RT-PCR. Expression levels are low, but sufficient to prevent development of G6pc2-specific T cells in thymus. (J:117352)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:117352
Krishnamurthy B et al.,
"Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP."
J Clin Invest 2006 Dec;116(12):3258-65
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All: |
2 reference(s)
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Analysis Tools
