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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(Tgfbr1*)Crm
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Benoit de Crombrugghe
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MGI ID: |
MGI:3785744 |
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Synonyms: |
TBR1CA |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134135
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo-STOP cassette followed by a cDNA encoding a constitutively active hemagglutinin-tagged Tgfbr1 was inserted into the locus. Expression of Tfgbr1 can only be detected upon cre-mediated removal of the neo-STOP cassette. (J:134135)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gt(ROSA)26Sor Mutation:
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196 strains or lines available |
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| References |
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Original: |
J:134135
Sonnylal S et al.,
"Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma."
Arthritis Rheum 2007 Jan;56(1):334-44
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All: |
1 reference(s)
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Analysis Tools
