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| Nomenclature |
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Symbol:
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Mus81tm1Esse
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Name:
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MUS81 endonuclease homolog (yeast);
targeted mutation 1, Jeroen Essers
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MGI ID: |
MGI:3785405 |
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Synonyms: |
Efemp2/Mus81tm1Esse, Fibulin-4R |
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Gene:
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Mus81
Location:
Chr19:5482345-5488402 bp, - strand
Genetic Position: Chr19,
4.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:133703
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 through 10 of Mus81 were replaced with a neo cassette. Reduction in expression of transcripts for both Mus81 and the neighboring gene Efemp2 was confirmed by quantitative RT-PCR on embryonic fibroblasts extracts. (J:133703)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mus81 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:133703
Hanada K et al.,
"Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice."
Circ Res 2007 Mar 16;100(5):738-46
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All: |
3 reference(s)
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Analysis Tools
