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| Nomenclature |
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Symbol:
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Tg(Thy1-SOD1*G93A)T1Hgrd
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Name:
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transgene insertion T1, Casper Hoogenraad
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MGI ID: |
MGI:3785266 |
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Transgene:
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Tg(Thy1-SOD1*G93A)T1Hgrd
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain adn spinal cord was determined by Western blot. Line T1 was used for further studies.
(J:134095)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:134095
Jaarsma D et al.,
"Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice."
J Neurosci 2008 Feb 27;28(9):2075-88
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All: |
1 reference(s)
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Analysis Tools
