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| Nomenclature |
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Symbol:
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Ugt1tm1Rhtu
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Name:
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UDP glucuronosyltransferase 1 complex;
targeted mutation 1, Robert H Tukey
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MGI ID: |
MGI:3784509 |
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Synonyms: |
Ugt1- |
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Gene:
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Ugt1
Location:
unknown
Genetic Position: Chr1,
Syntenic
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Ugt1tm1Rhtu/Ugt1tm1Rhtu mice are jaundiced and show postnatal lethality
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:133790
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neo cassette was inserted into exon 4 interrupting amino acid thr-413 and leu-414. The absence of protein products was confirmed by western blot analysis on liver extracts. Northern blot analysis confirmed the absence of all Ugt1a family RNAs in homozygous liver. Conjugation activity using bilirubin or T4 as substrates was absent from homozygous liver extracts. (J:133790)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:133790
Nguyen N et al.,
"Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease."
J Biol Chem 2008 Mar 21;283(12):7901-11
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All: |
3 reference(s)
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Analysis Tools
