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| Nomenclature |
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Symbol:
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Pla2g6tm1Tsu
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Name:
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phospholipase A2, group VI;
targeted mutation 1, Yoshihide Tsujimoto
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MGI ID: |
MGI:3777373 |
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Synonyms: |
iPLA2beta- |
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Gene:
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Pla2g6
Location:
Chr15:79286228-79328390 bp, - strand
Genetic Position: Chr15,
37.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:132853
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 9 was replaced with a neomycin resistance cassette. Immunoblot of testicular lysates indicated no protein expression of the targeted locus occurred in homozygotes. (J:132853)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pla2g6 Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:132853
Shinzawa K et al.,
"Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease."
J Neurosci 2008 Feb 27;28(9):2212-20
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All: |
3 reference(s)
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Analysis Tools
