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| Nomenclature |
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Symbol:
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Wwtr1tm1Hku
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Name:
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WW domain containing transcription regulator 1;
targeted mutation 1, Hiroki Kurihara
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MGI ID: |
MGI:3775483 |
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Synonyms: |
TazlacZ |
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Gene:
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Wwtr1
Location:
Chr3:57455649-57575910 bp, - strand
Genetic Position: Chr3,
27.74 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:132020
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Parent Cell Line:
| ATOM1 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The coding region in exon 2 was replaced with nls-lacZ/PGKneo cassette. The absence of transcripts and protein in homozygous mice was confirmed by RT-PCR and Western blotting. (J:132020)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wwtr1 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:132020
Makita R et al.,
"Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ."
Am J Physiol Renal Physiol 2008 Mar;294(3):F542-53
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All: |
3 reference(s)
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Analysis Tools
