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| Nomenclature |
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Symbol:
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Tg(Prnp-SMN)92Ahmb
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Name:
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transgene insertion 92, Arthur H M Burghes
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MGI ID: |
MGI:3774945 |
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Synonyms: |
PrP92-SMN |
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Transgene:
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Tg(Prnp-SMN)92Ahmb
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The PrP-SMN transgene was designed with the mouse prion protein gene (PrP or Prnp) promoter region and exon 1 and 2, full-length SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 92 (PrP92-SMN) were found to have 8-9 copies of the transgene. (J:131663)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:131663
Gavrilina TO et al.,
"Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect."
Hum Mol Genet 2008 Jan 4;():
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All: |
3 reference(s)
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Analysis Tools
