|
|
| Nomenclature |
|
Symbol:
|
Tg(ACTA1-SMN)69Ahmb
|
|
Name:
|
transgene insertion 69, Arthur H M Burghes
|
|
MGI ID: |
MGI:3774944 |
|
Synonyms: |
HSA69-SMN |
|
Transgene:
|
Tg(ACTA1-SMN)69Ahmb
Location:
unknown
|
|
Transgene
origin |
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The HSA-SMN transgene was designed with the human alpha-skeletal actin (HSA or ACTA1) promoter region, splice acceptor site from the SV40 VP1 intron, full-length humsn SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 69 (HSA69-SMN) were found to have 11 copies of the transgene. (J:97103, J:131663)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:131663
Gavrilina TO et al.,
"Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect."
Hum Mol Genet 2008 Jan 4;():
|
|
All: |
3 reference(s)
|
|
Analysis Tools
