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| Nomenclature |
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Symbol:
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Tg(Tcra,Tcrb)HRVAll
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Name:
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transgene insertion HRV, James P Allison
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MGI ID: |
MGI:3773740 |
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Synonyms: |
HRV TCR |
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Transgene:
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Tg(Tcra,Tcrb)HRVAll
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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either: C57BL/6 or (CBA x C57BL/6)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Rearranged Valpha2-SGTGGYKV TCRalpha and Vbeta8.3-SGTGGSAETL TCRbeta chains were cloned from a population of CD8+ T cells that recognizes a 17-mer peptide from the C-terminus of Histone 4 family members presented on H2-Kb. The recombined gene segments were placed in a TCR expression vector and injected into blastocytes. This founder line is characterized by "variegated" expression of the transgenic TCR with about 28% of CD8+ T cells expressing the transgenic TCR. (J:131347)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:131347
Savage PA et al.,
"Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes."
Science 2008 Jan 11;319(5860):215-20
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All: |
1 reference(s)
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Analysis Tools
