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| Nomenclature |
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Symbol:
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Tg(Prnp-TBP*)71-27Xjl
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Name:
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transgene insertion 71-27, Xiao-Jiang Li
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MGI ID: |
MGI:3772868 |
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Synonyms: |
TBP-71Q-27 |
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Transgene:
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Tg(Prnp-TBP*)71-27Xjl
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing the human TATA box binding protein, TBP, containing a 71 polyQ repeat expansion, under the control of the mouse prion protein promoter was injected into fertilized FVB/N mouse eggs. A second founder line TBP-71Q-27 was established, in addition to line 71Q-16. The 71 polyQ-expansion is detected in the cerebral cortex and cerebellum by Western blot analysis. (J:130775)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:130775
Friedman MJ et al.,
"Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration."
Nat Neurosci 2007 Dec;10(12):1519-28
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All: |
1 reference(s)
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Analysis Tools
