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| Nomenclature |
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Symbol:
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Slc40a1tm1Nca
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Name:
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solute carrier family 40 (iron-regulated transporter), member 1;
targeted mutation 1, Nancy C Andrews
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MGI ID: |
MGI:3771547 |
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Synonyms: |
Fpnnull |
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Gene:
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Slc40a1
Location:
Chr1:45908070-45925594 bp, - strand
Genetic Position: Chr1,
23.96 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:129846
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A floxed neo-cassette replaced exon 6 and part of exon 7 encoding amino acids 172 - 338 including 3 of the 10 predicted transmembrane segments. Immunohistochemical analysis confirmed the absence of protein in a subset of embryos from heterozygous crosses.(J:129846)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc40a1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:129846
Donovan A et al.,
"The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis."
Cell Metab 2005 Mar;1(3):191-200
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All: |
1 reference(s)
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Analysis Tools
