|
|
| Nomenclature |
|
Symbol:
|
Wnk4tm1Suc
|
|
Name:
|
WNK lysine deficient protein kinase 4;
targeted mutation 1, Shinichi Uchida
|
|
MGI ID: |
MGI:3771073 |
|
Synonyms: |
Wnk4D561A |
|
Gene:
|
Wnk4
Location:
Chr11:101260567-101277409 bp, + strand
Genetic Position: Chr11,
64.51 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:129716
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Nucleotide substitutions |
| |
|
Mutation details: A nucleotide substitution leading to the amino acid substitution of alanine for aspartic acid at position 561 (D561A) was knocked into exon 7 along with a floxed neo cassette that was subsequently removed by cre-mediated recombination. (J:129716)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:129716
Yang SS et al.,
"Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model."
Cell Metab 2007 May;5(5):331-44
|
|
All: |
5 reference(s)
|
|
Analysis Tools
