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| Nomenclature |
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Symbol:
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Del(7Herc2-Mkrn3)13FRdni
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Name:
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deletion, Chr 7, R D Nicholls13F;
deletion, Chr 7, R D Nicholls 13F
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MGI ID: |
MGI:3769770 |
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Synonyms: |
Del13FRdni, TgPWS/AS(del) |
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Gene:
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Del(7Herc2-Mkrn3)13FRdni
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: Transgene insertion of Tg(Igh-Lmp2a)13FRdni (MGI:3769767) resulted in a 5Mb deletion covering the entire Prader-Willi syndrom homology region. (J:56614, J:103338)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This deletion was generated in mice carrying Tg(Igh-Lmp2a)13FRdni. 9 lines were created with the eight others exhibiting lymphocyte cell lineage defects. Line 13F results in a deletion in chromosome 7 from Mkrn3 to Herc2 (Mkrn3, Ndn, Snurf/Snrpn, Ube3a, and Herc2 are deleted).
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| References |
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Original: |
J:56614
Gabriel JM et al.,
"A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes."
Proc Natl Acad Sci U S A 1999 Aug 3;96(16):9258-63
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All: |
6 reference(s)
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Analysis Tools
