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| Nomenclature |
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Symbol:
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Sirt3tm1.1Fwa
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Name:
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sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae);
targeted mutation 1.1, Frederick W Alt
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MGI ID: |
MGI:3769234 |
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Synonyms: |
Sirt3-, SIRT3- |
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Gene:
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Sirt3
Location:
Chr7:140863670-140882309 bp, - strand
Genetic Position: Chr7,
86.07 cM, cytoband F4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:129009
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A floxed neo cassette was inserted into intron 3 and an additional loxP site was inserted upstream of exon 2. Cre-mediated recombination was used to remove the neo cassette, exon 2 and exon 3. The absence of protein product was confirmed by western blot analysis on liver and brain extracts. (J:129009)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:129009
Lombard DB et al.,
"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation."
Mol Cell Biol 2007 Dec;27(24):8807-14
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All: |
11 reference(s)
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Analysis Tools
