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| Nomenclature |
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Symbol:
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Map2k4tm1Ctr
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Name:
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mitogen-activated protein kinase kinase 4;
targeted mutation 1, Cathy Tournier
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MGI ID: |
MGI:3769117 |
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Synonyms: |
mkk4fl, mkk4-flox |
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Gene:
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Map2k4
Location:
Chr11:65688243-65788297 bp, - strand
Genetic Position: Chr11,
40.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:129038
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo cassette was inserted downstream of exon 4 and an additional loxP site was inserted upstrem of exon 4. The floxed neo cassette was removed by cre-mediated recombination using a cre-expressing plasmid. (J:129038)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Map2k4 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:129038
Wang X et al.,
"Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death."
Mol Cell Biol 2007 Nov;27(22):7935-46
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All: |
6 reference(s)
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Analysis Tools
