Tg(Thy1-MAPT*P301L)2Vln
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT*P301L)2Vln
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Name:
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transgene insertion 2, Fred Van Leuven
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MGI ID: |
MGI:3768525 |
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Synonyms: |
tau-4R/2N-P301L |
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Transgene:
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Tg(Thy1-MAPT*P301L)2Vln
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts, and also carrying an engineered mutation to alter codon 301 from one encoding proline to encoding leucine, was inserted into a murine Thy1 expression vector. Expression of the mutant human tau (MAPT*P301L) protein was detected in layers II, V and VI of the neocortex, in layer III of the entorhinal cortex, in thd basolateral amygdala, hippocampus, zona incerta of the thalamus, brain stem nuclei and spinal cord. (J:96869)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:96869
Terwel D et al.,
"Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice."
J Biol Chem 2005 Feb 4;280(5):3963-73
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All: |
7 reference(s)
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Analysis Tools
