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| Nomenclature |
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Symbol:
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Tg(TcraR28,TcrbR28)KRNDim
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Name:
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transgene insertion KRN, Diane Mathis
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MGI ID: |
MGI:3767242 |
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Synonyms: |
K/B, KRN, KRN-TCR |
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Transgene:
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Tg(TcraR28,TcrbR28)KRNDim
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak. (J:36815)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:36815
Kouskoff V et al.,
"Organ-specific disease provoked by systemic autoimmunity."
Cell 1996 Nov 29;87(5):811-22
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All: |
47 reference(s)
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Analysis Tools
