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| Nomenclature |
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Symbol:
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Timo
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Name:
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transgenic insertional mutants with obesity
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MGI ID: |
MGI:3766100 |
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Gene:
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Timo
Location:
unknown
Genetic Position: Chr2,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/CaJ)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Insertion |
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Mutation details: A transgene containing a mouse Flk1 promotor, mouse Rage cDNA, and SV40 polyA signal inserted between 108,618,208 and 108,618,659 bp in Chromosome 2, approximately 857 kb upstream of the transcription start site of Bdnf. No transgene expression is seen. Bdnf mRNA and protein expression levels are reduced in the hippocampus and hypothalmus. Serum BDNF levels are about 30% of non-transgenic controls. Reduction in expression varies with the hypothalamus most severely affected followed by the hippocampus, but no significant reduction in expression in the lung. Several conserved elements are located in the insertion region and functional analysis indicated that some of these enhance Bdnf expression. (J:127183)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Timo Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:127183
Sha H et al.,
"Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice."
Physiol Genomics 2007 Oct 22;31(2):252-63
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All: |
1 reference(s)
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Analysis Tools
