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| Nomenclature |
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Symbol:
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Tg(COL1A1)73Prc
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Name:
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transgene insertion 73, Darwin J Prockop
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MGI ID: |
MGI:3766089 |
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Synonyms: |
line V |
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Transgene:
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Tg(COL1A1)73Prc
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: These mice express a mini-gene construct that contains the 5'- and 3'-ends of the human gene for the pro-alpha(1) collagen chain but lack a large central region containing 41 exons. The mini-gene includes 2.5 kilobases of the 5'-promoter region, the first 5 exons and introns, the last 6 exons and introns, and about 2 kilobases of the 3"flanking region. The junction between the 5'- and 3'-halves of the mini-gene was made in introns so as to preserve the consensus sequences for RNA splicing. Mice in this line carry about 20 copies of the transgene. (J:31417, J:146429)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:31417
Khillan JS et al.,
"Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta."
J Biol Chem 1991 Dec 5;266(34):23373-9
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All: |
6 reference(s)
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Analysis Tools
