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| Nomenclature |
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Symbol:
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Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
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Name:
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transgene insertion 21, Mathias Jucker
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MGI ID: |
MGI:3765351 |
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Synonyms: |
APPPS1, APPPS1-21 |
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Transgene:
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Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Thy1-APPKM670/671NL was constructed with the mutant human APPKM670/671NL cDNA (Swedish or KM670/671NL mutation of amyloid precursor protein (APP)) placed downstream of the murine Thy1.2 promoter region. Additionally, the Thy1-PS1L166P transgene was constructed with a mutant human PS1L166P cDNA (leucine to proline mutation at position 166 of human presenilin 1 (Alzheimer disease 3, PSEN1 or PS1)) placed downstream of the murine Thy1.2 promoter sequences. These constructs were coinjected to produce founder mice. In addition to line 21, lines 5 and 8 were also established. (J:116895)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:116895
Radde R et al.,
"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology."
EMBO Rep 2006 Sep;7(9):940-6
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All: |
27 reference(s)
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Analysis Tools
