|
|
| Nomenclature |
|
Symbol:
|
Tg(CAG-SNCA*)1.1Ccs
|
|
Name:
|
transgene insertion 1.1, Christine C Stichel
|
|
MGI ID: |
MGI:3764813 |
|
Synonyms: |
BAsyn, chbetaactin, Tg(ACTB-SNCA*)1.1Ccs, Tg(CAG-SNCA*)1.1Ccs |
|
Transgene:
|
Tg(CAG-SNCA*)1.1Ccs
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This transgene contains a double mutant human SNCA with amino acid substitutions of proline for alanine at position 30 (A30P) and threonine for alanine at position 53 (A53T) under the control of a CMV enchanced, chicken beta-actin promoter. Expression is detected in the brain, kidney, lung, liver and heart. (J:127708)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
|
Notes |
Four lines were created (1.10, 1.1, 1.5 and 1,9) with similar expression patterns and line 1.1 choosen as the representative line.
|
| References |
|
Original: |
J:127708
Maskri L et al.,
"Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice."
Neurodegener Dis 2004;1(6):255-65
|
|
All: |
3 reference(s)
|
|
Analysis Tools
