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| Nomenclature |
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Symbol:
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Tg(Ins2-Tnf)17Flv
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Name:
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transgene insertion 17, Richard Flavell
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MGI ID: |
MGI:3764663 |
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Synonyms: |
RIP-TNFalpha |
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Transgene:
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Tg(Ins2-Tnf)17Flv
Location:
unknown
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct contained the murine Tnf-alpha gene driven by the rat insulin 2 promoter (RIP). Founder mice carried the transgene with copy number ranging from 2-20 per genome. Line 17 was used for further study. Transcripts of the transgene were detected by Northern blot only in the pancreas of the mice. (J:91820)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:91820
Picarella DE et al.,
"Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice."
J Immunol 1993 May 1;150(9):4136-50
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All: |
4 reference(s)
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Analysis Tools
