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| Nomenclature |
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Symbol:
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Tg(Ins2-CD86)12B70Flv
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Name:
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transgene insertion 12B70, Richard Flavell
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MGI ID: |
MGI:3764558 |
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Synonyms: |
RIP-CD86 |
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Transgene:
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Tg(Ins2-CD86)12B70Flv
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA/Ca)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct contains the human CD86 gene driven by the rat insulin 2 promoter (RIP). Transgenic protein expression is restricted to the Islets of Langerhans. (J:93555)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93555
Guerder S et al.,
"Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes."
J Immunol 1998 Sep 1;161(5):2128-40
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All: |
3 reference(s)
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Analysis Tools
