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| Nomenclature |
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Symbol:
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Flt3tm1Dgg
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Name:
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FMS-like tyrosine kinase 3;
targeted mutation 1, D Gilliland
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MGI ID: |
MGI:3763385 |
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Synonyms: |
Flt3ITD, FLT3/ITD |
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Gene:
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Flt3
Location:
Chr5:147330741-147400489 bp, - strand
Genetic Position: Chr5,
86.88 cM, cytoband G3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:126003
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The human W51 mutation which causes the duplication of amino acid 596 to 602 (R-E-Y-E-Y-D-L) was inserted inframe into exon 14. A floxed neomycin selection cassette was inserted in intron 15 as well. DNA sequencing was performed to confirm the duplication in exon 14. (J:126003)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:126003
Lee BH et al.,
"FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia."
Cancer Cell 2007 Oct;12(4):367-80
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All: |
6 reference(s)
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Analysis Tools
