Tg(Itgax-cre)1-1Reiz
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Itgax-cre)1-1Reiz
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Name:
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transgene insertion 1-1, Boris Reizis
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MGI ID: |
MGI:3763248 |
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Synonyms: |
Cd11c-cre |
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Transgene:
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Tg(Itgax-cre)1-1Reiz
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%). (J:125869)
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Recombinase activity
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Activity in:
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adipose tissue,
alimentary system,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
muscle,
postnatal-other,
renal & urinary system,
reproductive system,
respiratory system
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Not detected in:
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cardiovascular system,
cavities & their linings,
embryo-other,
extraembryonic component,
limbs,
mesenchyme,
nervous system,
sensory organs,
skeletal system,
tail
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Driver:
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Itgax
Summary of all recombinase alleles
driven by Itgax.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:125869
Caton ML et al.,
"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen."
J Exp Med 2007 Jul 9;204(7):1653-64
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All: |
69 reference(s)
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Analysis Tools
