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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm9(cre/ESR1)Arte
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 9, TaconicArtemis
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MGI ID: |
MGI:3763211 |
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Synonyms: |
CreERT2, Ert2-Cre, Gt(ROSA)26Sortm1(cre/ESR1)Arte, Gt(ROSA)26Sortm9(Cre/ESR1)ArteCreERT2, Rosa26CreERT2, rosa26(SA-CreERT2)ARTE, Rosa(CreER+), rosa(CreERT2), rosa(SAcreERT2) |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:126518
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S6/SvEvTac)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. Following oral administration of tamoxifen recombination efficiency varies from up to 50% to almost 100% depending on the target allele and tissue. Recombination was lowest in the brain. (J:126518)
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Recombinase activity
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Driver:
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Gt(ROSA)26Sor
Summary of all recombinase alleles
driven by Gt(ROSA)26Sor.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gt(ROSA)26Sor Mutation:
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196 strains or lines available |
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Notes |
ES cell line = V6.5 [(C57BL/6 x 129S4/SvJae)F1] or ART4.12 [(C57BL/6 x 129S6/SvEvTac)F1].
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| References |
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Original: |
J:126518
Seibler J et al.,
"Rapid generation of inducible mouse mutants."
Nucleic Acids Res 2003 Feb 15;31(4):e12
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All: |
44 reference(s)
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Analysis Tools
