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| Nomenclature |
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Symbol:
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Emx1tm1.1(cre)Ito
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Name:
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empty spiracles homeobox 1;
targeted mutation 1.1, Shigeyoshi Itohara
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MGI ID: |
MGI:3762664 |
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Synonyms: |
Emx1-Cre KI deltaneo, Emx1tm2(cre)Ito |
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Gene:
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Emx1
Location:
Chr6:85187438-85204462 bp, + strand
Genetic Position: Chr6,
37.21 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88421
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A cDNA encoding Cre recombinase with an N-terminal nuclear localization signal (nls) resides immediately 5' of the translation initiation site of the endogenous gene. This allele was derived from Emx1tm1(cre)Ito by FLP recombinase excision of a FRT-flanked pgk-neo cassette that lay immediately downstream of the nls-cre gene. The Emx1 promoter drives Cre recombinase expression in the embryonic through adult dorsal telencephelon; deletion of the selection cassette reportedly prevents ectopic expression in other brain regions. (J:64064, J:104881)
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Recombinase activity
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Driver:
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Emx1
Summary of all recombinase alleles
driven by Emx1.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:88421
Iwasato T et al.,
"Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice."
Genesis 2004 Mar;38(3):130-8
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All: |
9 reference(s)
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Analysis Tools
