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| Nomenclature |
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Symbol:
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Lgr4tm1.2Knis
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Name:
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leucine-rich repeat-containing G protein-coupled receptor 4;
targeted mutation 1.2, Katsuhiko Nishimori
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MGI ID: |
MGI:3762641 |
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Gene:
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Lgr4
Location:
Chr2:109917647-110014257 bp, + strand
Genetic Position: Chr2,
56.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:127019
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Cre mediated recombination removed an Frt-flanked neo cassette and the part of exon 18 which codes for the transmembrane and signal-transducing domains. Immunostaining confirms the absence of expression in the protruding tips of the eyelids and in epithelial cells of the cornea. (J:126813, J:127019)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lgr4 Mutation:
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50 strains or lines available |
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| References |
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Original: |
J:127019
Kato S et al.,
"Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice."
Nephron Exp Nephrol 2006;104(2):e63-75
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All: |
5 reference(s)
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Analysis Tools
