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| Nomenclature |
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Symbol:
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Igh-Jtm2(3H9-VDJ*)Mwg
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Name:
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immunoglobulin heavy chain, joining region;
targeted mutation 2, Martin Weigert
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MGI ID: |
MGI:3762369 |
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Synonyms: |
3H9(56R), 3H9H56R, 3H9H/56R, 56R, 56Rki, VH56R |
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Gene:
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Igh-J
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:126940
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: The endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with an amino acid substitution of an arginine for an aspartate at position 56 (D56R) and a neomycin resistance gene. (J:126940)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:126940
Li H et al.,
"Editors and editing of anti-DNA receptors."
Immunity 2001 Dec;15(6):947-57
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All: |
19 reference(s)
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Analysis Tools
