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| Nomenclature |
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Symbol:
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Tg(CMV-Msx2*P7H)1Rem
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Name:
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transgene insertion 1, Robert E Maxson
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MGI ID: |
MGI:3762251 |
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Synonyms: |
CMV-Msx2-Pro7His |
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Transgene:
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Tg(CMV-Msx2*P7H)1Rem
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a 1.1-kb fragment of the mouse Msx2 gene containing 0.3 kb of the 3.5-kb intron and a PCR-mutagenized version of the second exon bearing the Pro7His mutation under the control of human cytomegalovirus (CMV) promoter. This single base pair mutation is seen in individuals affected with Boston-type craniosynostosis. (J:26513)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:26513
Liu YH et al.,
"Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull."
Proc Natl Acad Sci U S A 1995 Jun 20;92(13):6137-41
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All: |
1 reference(s)
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Analysis Tools
