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| Nomenclature |
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Symbol:
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Tg(MMTV-neu/OT-I/OT-II)CBnel
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Name:
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transgene insertion C, Brad Nelson
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MGI ID: |
MGI:3761163 |
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Synonyms: |
MMTV-HER2/Neu-Ovalbumin, neuOT-I/OT-II |
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Transgene:
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Tg(MMTV-neu/OT-I/OT-II)CBnel
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct was designed to tag T cell receptor-recognized ovalbumin epitopes SIIFEKL (CD8+, OT-1) and ISQAVHAAHAEINEAGR (CD4+, OT-II)with the rat Erbb2/HER-2/neu oncogene under the control of an MMTV promoter creating a fusion protein (termed neuOT-I/OT-II). The vector was injected into C57BL/6 oocytes. Line C was selected for further studies based on mammary-specific expression and favorable tumor latency and frequency. (J:122846)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:122846
Wall EM et al.,
"Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells."
Cancer Res 2007 Jul 1;67(13):6442-50
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All: |
3 reference(s)
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Analysis Tools
