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| Nomenclature |
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Symbol:
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Ightm1.2Rsky
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Name:
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immunoglobulin heavy chain complex;
targeted mutation 1.2, Klaus Rajewsky
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MGI ID: |
MGI:3760662 |
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Synonyms: |
IgHgamma1mu |
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Gene:
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Igh
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:125719
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Parent Cell Line:
| BALB/c-I (ES Cell) |
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Strain of Origin:
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BALB/cJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Inversion, Intergenic deletion |
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Mutation details: These mice are derived from chimeric mice produced during creation of the Ightm1.1Rsky mouse strain. Upon crossing the chimeras with Cre expressing transgenic mice, the CH region of the Igh locus is deleted and an inversion of the targeted construct also occurs. This places the mutant Ighg1 into the right orientation to express functional protein. B cells from these mice were found to exclusively express IgG1 antibodies in both a soluble and membrane bound form. (J:125719)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Igh Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:125719
Waisman A et al.,
"IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta."
J Exp Med 2007 Apr 16;204(4):747-58
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All: |
1 reference(s)
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Analysis Tools
