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| Nomenclature |
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Symbol:
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Magel2tm1Stw
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Name:
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melanoma antigen, family L, 2;
targeted mutation 1, Colin L Stewart
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MGI ID: |
MGI:3760092 |
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Synonyms: |
Magel2- |
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Gene:
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Magel2
Location:
Chr7:62376979-62381640 bp, + strand
Genetic Position: Chr7,
34.37 cM
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Older Magel2tm1Stw/Magel2+ females that inherit the mutant allele paternally lack corpora lutea in the ovaries
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:125637
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire open reading frame was replaced with a lacZ-neo cassette. The endogenous promoter drives the expression of lacZ as confirmed by a beta-galactosidase assay. The absence of the paternal transcript was confirmed by RT-PCR. (J:125637)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:125637
Kozlov SV et al.,
"The imprinted gene Magel2 regulates normal circadian output."
Nat Genet 2007 Oct;39(10):1266-72
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All: |
4 reference(s)
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Analysis Tools
