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| Nomenclature |
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Symbol:
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F10tm1Ccmt
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Name:
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coagulation factor X;
targeted mutation 1, Katherine A High
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MGI ID: |
MGI:3759686 |
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Gene:
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F10
Location:
Chr8:13037308-13056676 bp, + strand
Genetic Position: Chr8,
5.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:145092
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 8 and the polyadenylation signal were replaced with a neomycin resistance gene and a 3' partial hypoxanthine guanine phosphoribosyl transferase 1 gene. A "socket" targeting construct was used to permit subsequent knock-in. The absence of protein expression was confirmed by western blot analysis on plasma extracts. (J:145092)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any F10 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:145092
Tai SJ et al.,
"A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X."
J Thromb Haemost 2008 Feb;6(2):339-45
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All: |
1 reference(s)
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Analysis Tools
