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| Nomenclature |
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Symbol:
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Cln3tm1Blda
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Name:
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ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease);
targeted mutation 1, Beverly L Davidson
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MGI ID: |
MGI:3759415 |
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Synonyms: |
Cln3lacZ |
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Gene:
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Cln3
Location:
Chr7:126571207-126585817 bp, - strand
Genetic Position: Chr7,
69.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:125194
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Genomic sequence from the ATG in exon 1 through exons 8 was replaced with a beta-gal-pA and TKPneo cassette then knocked into the open reading frame to produce a null reporter allele. Expression of the lacZ was confirmed by X-gal assay and the absence of a transcript was confirmed RT-PCR. (J:125194)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cln3 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:125194
Eliason SL et al.,
"A knock-in reporter model of Batten disease."
J Neurosci 2007 Sep 12;27(37):9826-34
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All: |
3 reference(s)
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Analysis Tools
