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| Nomenclature |
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Symbol:
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Tg(Camk2a-DISC1)10Asaw
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Name:
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transgene insertion 10, Akira Sawa
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MGI ID: |
MGI:3758077 |
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Synonyms: |
DN_DISC1, DN-DISC1 |
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Transgene:
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Tg(Camk2a-DISC1)10Asaw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncate protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfer with endogenous gene expression from Disc. (J:124683)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Two lines were created (lines 10 and 37) that display similar phenotypes.
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| References |
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Original: |
J:124683
Hikida T et al.,
"From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans."
Proc Natl Acad Sci U S A 2007 Sep 4;104(36):14501-6
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All: |
5 reference(s)
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Analysis Tools
