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| Nomenclature |
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Symbol:
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Tg(Camk2a-DISC1)10Asaw
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Name:
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transgene insertion 10, Akira Sawa
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MGI ID: |
MGI:3758077 |
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Synonyms: |
DN_DISC1, DN-DISC1 |
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Transgene:
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Tg(Camk2a-DISC1)10Asaw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the low expressing line. (J:124683)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Two lines were created (lines 10 and 37) that display similar phenotypes.
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| References |
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Original: |
J:124683
Hikida T et al.,
"From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans."
Proc Natl Acad Sci U S A 2007 Sep 4;104(36):14501-6
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All: |
5 reference(s)
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Analysis Tools
