|
|
| Nomenclature |
|
Symbol:
|
Tg(Myh6-tTA)55Rbns
|
|
Name:
|
transgene insertion 55, Jeffrey Robbins
|
|
MGI ID: |
MGI:3757936 |
|
Synonyms: |
alpha-MHC-tTA |
|
Transgene:
|
Tg(Myh6-tTA)55Rbns
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
Not Specified
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This transgene consists of the tetracycline transactivator (a chimeric tTA fusion protein of the Tn10 Tet resistance operon in E.coli and the carboxy-terminal portion of the transactivator protein from herpes simplex virus -VP16) under the control of the cardiac specific mouse alpha myosin heavy chain. Although transgene protein expression is not detected in the heart via Western blot, when transgenics are crossed with Tg(tetop-lacZ)2Mam, uniform and robust expression of lacZ is seen in the hearts, indicating that very low levels of tTA protein are present to induce lacZ expression. (J:125131)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:125131
Sanbe A et al.,
"Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter."
Circ Res 2003 Apr 4;92(6):609-16
|
|
All: |
23 reference(s)
|
|
Analysis Tools
