Tg(Prnp-SNCA*A53T)AAub
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Prnp-SNCA*A53T)AAub
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Name:
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transgene insertion A, Georg Auburger
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MGI ID: |
MGI:3723258 |
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Synonyms: |
A53T, PrPmtA, PrPmtB, Tg(Prnp-SNCA*A53T)BAub |
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Transgene:
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Tg(Prnp-SNCA*A53T)AAub
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A construct containing the entire translated portion of human alpha-synuclein, SNCA from position 22 to 515, driven by an ~3.5 kb fragment of the mouse prion protein promoter, Prnp, was generated. The SNCA cDNA was followed by polyadenylation sequences derived from the 3' untranslated region of the boving growth hormone gene. This construct was microinjected into pronuclei of fertilized FVB/N ova.
Transgenic protein expression was detected in the neuropil, with, more rarely, additional protein within neuronal cell bodies and neurites in the brain and motoneurons in the spinal cord. Two lines, A and B, were generated, have both been extensively studied, showing extremely similar phenotypes (J:86222, J:124976). (J:86222)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:86222
Gispert S et al.,
"Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation."
Mol Cell Neurosci 2003 Oct;24(2):419-29
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All: |
7 reference(s)
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Analysis Tools
