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| Nomenclature |
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Symbol:
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Tg(Thy1-BACE1)16Vln
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Name:
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transgene insertion 16, Fred Van Leuven
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MGI ID: |
MGI:3722132 |
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Synonyms: |
BACE |
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Transgene:
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Tg(Thy1-BACE1)16Vln
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 and DBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A construct containing the human BACE1 cDNA inserted in the mouse Thy1 gene cassette in the pTSC plasmid was microinjected into day 0.5 pronuclear DBA/C57BL/6 embryos. 5 founders were generated and line 16 was found to have high human BACE1 expression by Western blot. Line 16 was established for further use and characterization. (J:93635)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:93635
Willem M et al.,
"beta-Site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice."
Am J Pathol 2004 Nov;165(5):1621-31
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All: |
3 reference(s)
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Analysis Tools
