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| Nomenclature |
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Symbol:
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Tg(Thy1-APPSwDutIowa)BWevn
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Name:
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transgene insertion B, William E Van Nostrand
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MGI ID: |
MGI:3721992 |
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Synonyms: |
APPSwDI, Tg-SwDI, Tg-SwDI/B |
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Transgene:
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Tg(Thy1-APPSwDutIowa)BWevn
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing 2.1kb of the human amyloid beta-precursor protein, APP gene, 770 isoform, with the Swedish K670N/M671L, Dutch E693Q and Iowa D694N mutations, under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter was injected into fertilized C57BL/6 mouse eggs. Founder line B was subsequently established and homozygotes generated. Human amyloid beta precursor protein expression is detected in the brains of transgenic mice. Two other lines, A anc C were also generated, with line A having similar levels of transgene expression and amyloid beta accumulation to line B while line C has 2-fold higher expression of human Amyloid beta-precursor protein and shows 4-fold higher accumulations of soluble and insoluble AB peptides in the brain. (J:89848)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:89848
Davis J et al.,
"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor."
J Biol Chem 2004 May 7;279(19):20296-306
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All: |
21 reference(s)
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Analysis Tools
