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| Nomenclature |
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Symbol:
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Gabrg2tm1Wul
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Name:
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gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2;
targeted mutation 1, Peter Wulff
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MGI ID: |
MGI:3721943 |
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Synonyms: |
gamma2I77lox |
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Gene:
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Gabrg2
Location:
Chr11:41910203-42000857 bp, - strand
Genetic Position: Chr11,
24.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:124171
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 4 was replaced with an exon containing a phenylalanine to isoleucine mutation at position 77 (F77I). This point mutation confers drug insensitivity to zolpidem. A loxP site was inserted in the upstream intron and a frt-flanked neomycin cassette followed by another loxP site was inserted in the downstream intron. Chimeric mice were mated with a Flp deleter strain to remove the neomycin cassette. Genomic sequencing of homozygous mice confirmed the presence of the F to I mutation.
(J:124171)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:124171
Wulff P et al.,
"From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors."
Nat Neurosci 2007 Jul;10(7):923-9
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All: |
5 reference(s)
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Analysis Tools
