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| Nomenclature |
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Symbol:
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Plectm4Gwi
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Name:
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plectin;
targeted mutation 4, Gerhard Wiche
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MGI ID: |
MGI:3721885 |
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Synonyms: |
Plecflox |
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Gene:
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Plec
Location:
Chr15:76170975-76232574 bp, - strand
Genetic Position: Chr15,
35.48 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:124213
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A FRT-flanked neo cassette followed by a loxP site was inserted in the intron 25 of the targeted gene. An additional loxP site was added to intron 31. Mice were bred to Flpe-expressing mice to excise the neo cassette, leaving exons 26 through 31 flanked by loxP sites. (J:124213)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Plec Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:124213
Ackerl R et al.,
"Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects."
J Cell Sci 2007 Jul 15;120(Pt 14):2435-43
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All: |
4 reference(s)
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Analysis Tools
