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| Nomenclature |
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Symbol:
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Tg(Ckm-APPSw)A2Lfa
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Name:
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transgene insertion A2, Frank M LaFerla
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MGI ID: |
MGI:3720795 |
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Synonyms: |
A2 line, Tg(Ckm-APP*K670N*M671L)A2Lfa |
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Transgene:
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Tg(Ckm-APPSw)A2Lfa
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Human APP cDNA harboring the Swedish double mutation (K670N,M671L) was inserted downstream of the 1.3 kb 5' flanking sequence of the mouse muscle creatine kinase Ckm, upstream of the SV40 polyadenylation signal. The 3.8 kb construct was microinjected into pronuclei of single-cell C57Bl/6 x SJL embryos. Northern blot showed relatively low expression of the transgene in skeletal muscle of line A2 mice. (J:76338)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:76338
Sugarman MC et al.,
"Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle."
Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6334-9
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All: |
1 reference(s)
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Analysis Tools
