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| Nomenclature |
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Symbol:
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Tg(DMD-APP*)7Neve
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Name:
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transgene insertion 7, Rachel L Neve
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MGI ID: |
MGI:3720652 |
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Synonyms: |
APP-C100, BetaAPP-C104 |
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Transgene:
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Tg(DMD-APP*)7Neve
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A fragment consisting composed of the sequence ot the terminal 100 amino acids of the beta-amyloid precursor protein (APP) gene (C104, referred to as C100 in J:100978 which states that the transgene contains the terminal 100 amino acids of APP) was inserted into a plasmid encoding the neural-specific dystrophin (DMD) promoter. The vector also contained the SV40 early splice and polyadenylation sequences. Several founder lines were identified, but line 7 was the most extensively characterized line. RT-PCR of tissues from 6-month old mice revealed predominant expression in the brain (>10-fold higher than in any other tissue where low level-transcription was detected). (J:100978, J:105050)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:105050
Kammesheidt A et al.,
"Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain."
Proc Natl Acad Sci U S A 1992 Nov 15;89(22):10857-61
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All: |
2 reference(s)
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Analysis Tools
