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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT)1Vln
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Name:
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transgene insertion 1, Fred Van Leuven
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MGI ID: |
MGI:3720113 |
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Synonyms: |
htau40-1, tau-4R/2N, thy-1.1-tau |
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Transgene:
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Tg(Thy1-MAPT)1Vln
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Human MAPT cDNA encoding the longest tau isoform of 441 amino acids (called tau40) containing four repeats, with 2 N-terminal inserts was inserted into a murine Thy1 expression vector. Founder line 1 was established by breeding with FVB/N females. Expression of human tau (MAPT) protein exclusively in brain and spinal cord was detected by Western blotting. (J:100972)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:100972
Spittaels K et al.,
"Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein."
Am J Pathol 1999 Dec;155(6):2153-65
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All: |
5 reference(s)
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Analysis Tools
