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| Nomenclature |
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Symbol:
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Lats2tm1Noj
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Name:
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large tumor suppressor 2;
targeted mutation 1, Hiroshi Nojima
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MGI ID: |
MGI:3719818 |
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Synonyms: |
Lats2- |
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Gene:
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Lats2
Location:
Chr14:57642077-57758388 bp, - strand
Genetic Position: Chr14,
30.28 cM
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Lats2tm1Noj/Lats2tm1Noj embryos exhibit severe nervous system developmental defects
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:123480
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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The entire coding region was disrupted by replacing the first coding exon with the neo cassette. (J:123480)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lats2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:123480
Yabuta N et al.,
"Lats2 is an essential mitotic regulator required for the coordination of cell division."
J Biol Chem 2007 Jun 29;282(26):19259-71
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All: |
2 reference(s)
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Analysis Tools
