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| Nomenclature |
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Symbol:
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Tg(PDGFB-APPSwInd)J9Lms
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Name:
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transgene insertion J9, Lennart Mucke
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MGI ID: |
MGI:3717718 |
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Synonyms: |
APPSw,Ind, hAPPJ9, Tg(PDGFB-APP*)J9Lms |
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Transgene:
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Tg(PDGFB-APPSwInd)J9Lms
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. The Swedish APP (K670N/M671L) mutation was introduced into the construct by PCR primer modification. The modified construct was microinjected into (C57BL/6 x DBA/2)F2 one-cell embryos. Mice show high levels of amyloid beta deposits in their hippocampi. (J:23080, J:100974)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:100974
Hsia AY et al.,
"Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models."
Proc Natl Acad Sci U S A 1999 Mar 16;96(6):3228-33
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All: |
21 reference(s)
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Analysis Tools
