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| Nomenclature |
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Symbol:
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Tg(Gfap-TGFB1)64Lms
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Name:
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transgene insertion 64, Lennart Mucke
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MGI ID: |
MGI:3717676 |
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Synonyms: |
GFAP/TGF-B1, pTGF-B1 |
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Transgene:
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Tg(Gfap-TGFB1)64Lms
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(BALB/c x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The construct contains a 1.35 kb porcine transforming growth factor beta 1 (TGFB1) cDNA inserted into the first exon of the mouse glial fibrillary acidic protein (Gfap) gene, making a fusion gene The TGFB1 cDNA has been mutated to encode serines at positions 223 and 225, instead of cysteines, to ensure secretion of a bioactive peptide. The linear construct was microinjected into (BALB/c x SJL)F2 one-cell stage embryos. Line 64 founder mice expressed low levels of TGFB1 mRNA in the brain. Line 115 was also generated and shows very similar properties. (J:27781)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:27781
Wyss-Coray T et al.,
"Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1."
Am J Pathol 1995 Jul;147(1):53-67
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All: |
11 reference(s)
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Analysis Tools
