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| Nomenclature |
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Symbol:
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Tg(Thy1-APPLon)2Vln
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Name:
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transgene insertion 2, Fred Van Leuven
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MGI ID: |
MGI:3717572 |
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Synonyms: |
APP/Ld/2, APP/V717I, Tg(Thy1-APP*V642I)2Vln |
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Transgene:
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Tg(Thy1-APPLon)2Vln
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: cDNA encoding the human London (V642I) amyloid precursor protein variant (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:53800
Moechars D et al.,
"Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain."
J Biol Chem 1999 Mar 5;274(10):6483-92
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All: |
21 reference(s)
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Analysis Tools
